This course focuses on cellular physiologic and pathophysiologic processes through the lifespan, in order to provide a foundation for holistic clinical assessment, decision-making, and clinical management. Emphasis is on common altered health states based on current epidemiological trends. Special emphasis is given to pathogenesis, alterations in normal function, and the body’s adaptation to the disease process. Integration of current research from nursing and other disciplines is used to explore pathophysiologic processes, compensatory mechanisms, and the rationale for clinical interventions. Course content includes concepts of altered health in children and older adults, genetic and congenital disorders, neoplasia, disorder in hematopoietic function, and alterations and adaptations in cardiovascular, respiratory, urinary, endocrine, and nervous systems.